4.6 Review

The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses

Journal

CANCERS
Volume 11, Issue 10, Pages -

Publisher

MDPI
DOI: 10.3390/cancers11101469

Keywords

apoptosis; immune regulation; tumor; myeloid cells; lymphoid cells

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Funding

  1. TUBITAK [118Z363, 118Z997]
  2. H2020-MSCA-RISE-2017 grant [777995]

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Expression of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular.

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