Journal
NATURE MICROBIOLOGY
Volume 4, Issue 12, Pages 2039-2043Publisher
NATURE RESEARCH
DOI: 10.1038/s41564-019-0566-7
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Funding
- Collaborative Research Fund from the Research Grant Council of the Government of Hong Kong Special Administrative Region [C5026-16G]
- Research Impact Fund [R5011-18F]
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A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.
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