Journal
CHEMISTRYSELECT
Volume 4, Issue 29, Pages 8602-8605Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201900150
Keywords
Decarboxylative aldol reaction; 3-Hydroxy-oxindole; In-situ methyl enolate; beta-Ketoacid; WERSA
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Funding
- UGC
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Facile synthesis of bioactive 3-hydroxy-oxindole by decarboxylative aldol reaction via in-situ generated methyl enolate of beta-ketoacid and isatin in Water Extract of Rice Straw Ash (WERSA) is described. This method provides clean, simple and useful alternative to synthesize 3-hydroxy-oxindole. The products were isolated in excellent yield without using column chromatography. The green chemistry matrices calculated, and it also shows green protocol used.
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