Journal
CHEMISTRYSELECT
Volume 4, Issue 31, Pages 9238-9240Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201901655
Keywords
1; 2; 4-Triazole; Sonogashira reaction; Aryl iodide; Terminal alkyne
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Funding
- Research Council of the Shahrood University of Technology
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The synthesis of 2-substituted thiazolo[3,2-b] [1,2,4]triazoles is accomplished copper-free, Pd-catalyzed Sonogashira reaction of 6-(iodomethyl)-2-methylthiazolo[3,2-b][1,2,4]triazole with terminal alkynes in DMF at 70 degrees C. The coupling reaction of phenylacetylene and 4-ethynyltoluene gave the desired products in high yields. While, the Sonogashira reaction of alkynes such as 1-hexyne, 1-octyne, propargyl alcohols, and propargyl amines afforded the products in good yields.
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