Journal
JOURNAL OF SYNCHROTRON RADIATION
Volume 26, Issue -, Pages 1820-1825Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1600577519009329
Keywords
serial crystallography; sample delivery; fixed targets; acoustic dispensing
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Funding
- Diamond Light Source from the UK Government
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust [102593]
- Royal Society Wolfson Fellowship [RSWF\R2\182017]
- Wellcome Investigator Award in Science [210734/Z/18/Z]
- Wellcome Trust [210734/Z/18/Z] Funding Source: Wellcome Trust
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Efficient sample delivery is an essential aspect of serial crystallography at both synchrotrons and X-ray free-electron lasers. Rastering fixed target chips through the X-ray beam is an efficient method for serial delivery from the perspectives of both sample consumption and beam time usage. Here, an approach for loading fixed targets using acoustic drop ejection is presented that does not compromise crystal quality, can reduce sample consumption by more than an order of magnitude and allows serial diffraction to be collected from a larger proportion of the crystals in the slurry.
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