Journal
INFLAMMOPHARMACOLOGY
Volume 28, Issue 1, Pages 289-297Publisher
SPRINGER BASEL AG
DOI: 10.1007/s10787-019-00632-2
Keywords
Rhynchosia minima root; Anti-inflammation; Nf-kappa b; MAPK; Flavonoids
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Funding
- program for scientific research start-up funds of Guangdong Ocean University [R19009] Funding Source: Medline
- the Macao Science and Technology Development Fund [070/2017/A2, 041/2016/A] Funding Source: Medline
- the Research Fund of the University of Macau [MYRG2018-00176-ICMS] Funding Source: Medline
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Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound composition of EEF6 was determined by high-performance liquid chromatography-mass spectrometry. The result showed that five flavonoids compounds, 2 ',4 ',5,7-tetrahydroxyisoflavone, genistein-8-C-glucopyranoside, tricin, genistein, and daidzein, were identified in EEF6. In addition, EEF6 exhibited potent anti-inflammatory ability against LPS-stimulated RAW 264.7 cells via MAPK/NF-kappa B signaling pathways by decreasing the secretion of nitric oxide (NO), interleukin (IL)-6, TNF-alpha, and monocyte chemotactic protein (MCP)-1, inhibiting the translocation of p65 from cytoplasm to nucleus, and suppressing the phosphorylation of ERK, JNK, and p38. These results indicated that EEF6 could be a promising ingredient for inflammation management.
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