Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02035
Keywords
human monocytes; atherosclerosis; diet; respiratory diseases; neurodegeneration
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, Germany's Excellence Strategy) [EXC2151-390873048, GRK 2168]
- European Union's Horizon 2020 research and innovation program [733100]
- ERA-CVD JTC 2018
- BMBF (Diet-BB)
- Helmholtz
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Human monocytes are divided in three major populations; classical (CD14(+)CD16(-)), non-classical (CD14(dim)CD16(+)), and intermediate (CD14(+)CD16(+)). Each of these subsets is distinguished from each other by the expression of distinct surface markers and by their functions in homeostasis and disease. In this review, we discuss the most up-to-date phenotypic classification of human monocytes that has been greatly aided by the application of novel single-cell transcriptomic and mass cytometry technologies. Furthermore, we shed light on the role of these plastic immune cells in already recognized and emerging human chronic diseases, such as obesity, atherosclerosis, chronic obstructive pulmonary disease, lung fibrosis, lung cancer, and Alzheimer's disease. Our aim is to provide an insight into the contribution of human monocytes to the progression of these diseases and highlight their candidacy as potential therapeutic cell targets.
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