Journal
APPLIED SCIENCES-BASEL
Volume 9, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/app9163232
Keywords
gold nanoparticles; gold nanorods; nanoradiocompounds; radiopharmaceuticals; drug delivery; theragnostic; nuclear medicine; nanomedicine
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Funding
- Grant of Excellence Departments, MIUR [COMMI 314-337 LEGGE 232/2016]
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In the last decade, many innovative nanodrugs have been developed, as well as many nanoradiocompounds that show amazing features in nuclear imaging and/or radiometabolic therapy. Their potential uses offer a wide range of possibilities. It can be possible to develop nondimensional systems of existing radiopharmaceuticals or build engineered systems that combine a nanoparticle with the radiopharmaceutical, a tracer, and a target molecule, and still develop selective nanodetection systems. This review focuses on recent advances regarding the use of gold nanoparticles and nanorods in nuclear medicine. The up-to-date advancements will be shown concerning preparations with special attention on the dimensions and functionalizations that are most used to attain an enhanced performance of gold engineered nanomaterials. Many ideas are offered regarding recent in vitro and in vivo studies. Finally, the recent clinical trials and applications are discussed.
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