Journal
ADVANCED SCIENCE
Volume 6, Issue 21, Pages -Publisher
WILEY
DOI: 10.1002/advs.201900709
Keywords
atomic force microscopy; mechanobiology; nuclear envelope
Categories
Funding
- German Research Foundation (DFG) [LI 2157]
- Cluster of excellence Cells in Motion flexible funds grant [FF-2016-05]
- DFG [SH 167/6-1]
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The nuclear envelope is an undisputed component of the intracellular mechanotransduction cascades which collect, process, and respond to mechanical stimuli from the environment. At the same time, the nuclear envelope performs the function of a selective barrier between the nuclear and cytoplasmic compartments. Although the mechanosensing and the barrier functions of the nuclear envelope have both been subjects of intense research, a possible reciprocal relationship between them is only beginning to emerge. In this report, the role of the nucleocytoplasmic permeability barrier is evaluated in nuclear mechanics. Using a combination of atomic force and confocal microscopy, the functional state of the nucleocytoplasmic permeability barrier and the nuclear mechanics is monitored. By modulating the stringency of the barrier and simulating the active transport imbalance across the nuclear envelope, the decisive impact of these parameters on nuclear mechanics is demonstrated. It is concluded that the nucleocytoplasmic barrier is the second essential component of the intracellular mechanostat function performed by the nuclear envelope.
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