Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 5, Issue 10, Pages 5384-5391Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.9b00990
Keywords
egg white; eggshell; biomimetic hybrid scaffolds; bone regeneration
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Funding
- National Natural Science Foundation of China [51503129]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06S029]
- Science and Technology Program of Guangzhou [201707010094]
- Science and Technology Planning Project of Shenzhen [JCYJ20170307141438157, JCYJ20180307163534533]
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Designing biomimetic scaffolds that can provide an appropriate microenvironment in bone defects to accelerate bone regeneration may become the breach of bone tissue engineering. Herein, we present simple egg white (EW)-/eggshell (ES)-based biomimetic hybrid hydrogels to investigate their potential for promoted bone regeneration. The photopolymerized biomimetic hybrid hydrogels possessed porous structures, which may support cell growth. Remarkably, the addition of eggshells could benefit mechanical performance with good cytocompatibility. Moreover, biomimetic hybrid hydrogels could have effects on macrophages and regulate the osteogenic differentiation of human dental pulp stem cells, indicating their potential for enhanced bone regeneration. All of the results suggested that biomimetic hybrid scaffolds possess a promising prospect in bone tissue engineering with good bioactivity and low cost.
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