Journal
BIOCHEMISTRY
Volume 55, Issue 33, Pages 4636-4641Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.6b00565
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Funding
- National Institutes of Health [DA033760, DK909810]
- Leona M. and Harry B. Helmsley Charitable Trust [2012-PG-MED002]
- National Cancer Institute Cancer Center Support Grant [P30 (CA014195)]
- Dr. Frederick Paulsen Chair/Ferring Pharmaceuticals [DK098002]
- JPB foundation
- Hewitt Foundation
- Chapman Charitable Trust Fellowship
- UCSD Medical Scientist Training Program funding [T32 GM007198]
- Irving S. Sigal postdoctoral fellowship from the American Chemical Society
- Western Norway Regional Health Authority
- Novo Nordisk Foundation
- KG Jebsen Foundation
- [DK106210]
- Novo Nordisk Fonden [NNF14OC0010659, NNF15OC0016330] Funding Source: researchfish
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A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here, we identified and validated carboxyl ester lipase (CEL), a pancreatic enzyme hydrolyzing cholesteryl esters and other dietary lipids, as a FAHFA hydrolase. Variants of CEL have been linked to maturity-onset diabetes of the young, type 8 (MODY8), and to chronic pancreatitis. We tested the FAHFA hydrolysis activity of the CEL MODY8 variant and found a modest increase in activity as compared with that of the normal enzyme. Together, the data suggest that CEL might break down dietary FAHFAs.
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