Journal
PEERJ
Volume 7, Issue -, Pages -Publisher
PEERJ INC
DOI: 10.7717/peerj.7224
Keywords
Serine protease inhibitors; Disease; Homeostasis; Function; Human gut microbiota
Categories
Funding
- Microbiology and the Food Chain division (MICA) of the INRA institute through the metaprogramme MEM - Meta-omics and microbial ecosystems
- ANR
- CMCU-PHC Utique - Campus France [19G0819, 41786NC]
- SerpinGuTarget [ANR-14-CE16-0018]
- Titan [ANR-18-CE18-0019-03]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE16-0018] Funding Source: Agence Nationale de la Recherche (ANR)
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Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets. Several studies provided functional and structural data about human serpins. By comparison, only little knowledge regarding bacterial serpins exists. Through the emergence of metagenomic studies, many bacterial serpins were identified from numerous ecological niches including the human gut microbiota. The origin, distribution and function of these proteins remain to be established. In this report, we shed light on the key role of human and bacterial serpins in health and disease. Moreover, we analyze their function, phylogeny and ecological distribution. This review highlights the potential use of bacterial serpins to set out new therapeutic approaches.
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