Journal
NANOMATERIALS
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/nano9081148
Keywords
ionic liquid; polymer; PLGA; nanoparticle; poorly soluble drug; rutin; drug delivery; hybrid system
Categories
Funding
- FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020-Operational Programme for Competitiveness and Internationalization (POCI)
- FCT-Fundacao para a Ciencia e a Tecnologia (FCT) [POCI-01-0145-FEDER-032610-PTDC/MEC-DER/32610/2017]
- FCT [UID/DTP/04567/2019, UID/DTP/04567/2016]
- ALIES, Portugal
Ask authors/readers for more resources
The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work was to evaluate the potential of IL-polymer nanoparticle hybrid systems as tools to deliver poorly soluble drugs. These systems were obtained using a methodology previously developed by our group and improved herein to produce IL-polymer nanoparticle hybrid systems. Two different choline-based ILs and poly (lactic-co-glycolic acid) (PLGA) 50:50 or PLGA 75:25 were used to load rutin into the delivery system. The resulting rutin-loaded IL-polymer nanoparticle hybrid systems presented a diameter of 250-300 nm, with a low polydispersity index and a zeta potential of about -40 mV. The drug association efficiency ranged from 51% to 76%, which represents a good achievement considering the poor solubility of rutin. No significant particle aggregation was obtained upon freeze-drying. The presence of the IL in the nanosystem does not affect its sustained release properties, achieving about 85% of rutin released after 72 h. The cytotoxicity studies showed that the delivery system was not toxic to HaCat cells. Our findings may open a new paradigm on the therapy improvement of diseases treated with poorly soluble drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available