4.6 Review

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens

Ilse Delint-Ramirez et al.

MOLECULAR PSYCHIATRY (2020)

Review Pharmacology & Pharmacy

Allosteric Modulators of Sigma-1 Receptor

Edijs Vavers et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Neurosciences

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Chelsy R. Eddings et al.

NEUROBIOLOGY OF DISEASE (2019)

Article Behavioral Sciences

Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor

Tangui Maurice et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

Article Biochemistry & Molecular Biology

Structural basis for σ1 receptor ligand recognition

Hayden R. Schmidt et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Neurosciences

Pridopidine: Overview of Pharmacology and Rationale for its Use in Huntington's Disease

Susanna Waters et al.

JOURNAL OF HUNTINGTONS DISEASE (2018)

Article Cell Biology

Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense

Tzu-Yu Weng et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Multidisciplinary Sciences

The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission

Danielle O. Sambo et al.

NATURE COMMUNICATIONS (2017)

Article Pharmacology & Pharmacy

Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel

Kang Zhang et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Multidisciplinary Sciences

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

Ekaterina Pchitskaya et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, Research & Experimental

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice

Marta Garcia-Miralles et al.

JCI INSIGHT (2017)

Article Medicine, Research & Experimental

Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease

A. V. Bol'shakova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Review Cell Biology

Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases

Tzu-Yu Weng et al.

JOURNAL OF BIOMEDICAL SCIENCE (2017)

Article Biochemistry & Molecular Biology

Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes

Shafiul Alam et al.

BIOSCIENCE REPORTS (2017)

Article Biochemistry & Molecular Biology

Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors

G. Cristina Brailoiu et al.

BIOCHEMICAL JOURNAL (2016)

Article Cell Biology

Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury

Hui Dong et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)

Article Clinical Neurology

AF710B, a Novell M1/sigma 1 Agonist With Therapeutic Efficacy on Animal Models of Alzheimer's Disease

Abraham Fisher et al.

NEURODEGENERATIVE DISEASES (2016)

Article Neurosciences

Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity

Yun Wang et al.

CNS NEUROSCIENCE & THERAPEUTICS (2016)

Article Medicine, Research & Experimental

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS

Seiji Watanabe et al.

EMBO MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Pridopidine activates neuroprotective pathways impaired in Huntington Disease

Michal Geva et al.

HUMAN MOLECULAR GENETICS (2016)

Article Cell Biology

Sigmal receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orail

Shyam Srivats et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

Crystal structure of the human σ1 receptor

Hayden R. Schmidt et al.

NATURE (2016)

Article Clinical Neurology

SIGMAR1 mutation associated with autosomal recessive Silver-like syndrome

Alejandro Horga et al.

NEUROLOGY (2016)

Review Pharmacology & Pharmacy

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

Tsung-Ping Su et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Article Biochemistry & Molecular Biology

Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria

Nino Natsvlishvili et al.

BMC BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Solution NMR studies reveal the location of the second transmembrane domain of the human sigma-1 receptor

Jose Luis Ortega-Roldan et al.

FEBS LETTERS (2015)

Review Pharmacology & Pharmacy

Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS)

Timur A. Mavlyutov et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2015)

Article Neurosciences

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

Elena Popugaeva et al.

MOLECULAR NEURODEGENERATION (2015)

Article Multidisciplinary Sciences

Labelling and optical erasure of synaptic memory traces in the motor cortex

Akiko Hayashi-Takagi et al.

NATURE (2015)

Article Clinical Neurology

A SIGMAR1 splice-site mutation causes distal hereditary motor neuropathy

Xiaobo Li et al.

NEUROLOGY (2015)

Article Neurosciences

RAN Translation in Huntington Disease

Monica Banez-Coronel et al.

NEURON (2015)

Article Multidisciplinary Sciences

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

Shang-Yi A. Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope

Shang-Yi A. Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Subcellular Localization of the Sigma-1 Receptor in Retinal Neurons - an Electron Microscopy Study

Timur A. Mavlyutov et al.

SCIENTIFIC REPORTS (2015)

Article Neurosciences

Amyloid-beta Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes

Bernadette Schreiner et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Biochemistry & Molecular Biology

The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands

Katarzyna A. Gromek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Geriatrics & Gerontology

Mutations in UBQLN2 and SIGMAR1 genes are rare in Korean patients with amyotrophic lateral sclerosis

Hee-Jung Kim et al.

NEUROBIOLOGY OF AGING (2014)

Article Neurosciences

Co-administration of the Dopaminergic Stabilizer Pridopidine and Tetrabenazine in Rats

Susanna Waters et al.

JOURNAL OF HUNTINGTONS DISEASE (2014)

Article Biochemistry & Molecular Biology

Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions

Jose Luis Ortega-Roldan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Clinical Neurology

The dopaminergic stabilizer pridopidine increases neuronal activity of pyramidal neurons in the prefrontal cortex

Benjamin Gronier et al.

JOURNAL OF NEURAL TRANSMISSION (2013)

Letter Biochemistry & Molecular Biology

The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the sigma-1 receptor

K. Sahlholm et al.

MOLECULAR PSYCHIATRY (2013)

Article Clinical Neurology

A Randomized, Double-Blind, Placebo-Controlled Trial of Pridopidine in Huntington's Disease

Karl Kieburtz et al.

MOVEMENT DISORDERS (2013)

Article Neurosciences

LACK OF SIGMA-1 RECEPTOR EXACERBATES ALS PROGRESSION IN MICE

T. A. Mavlyutov et al.

NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers

Gemma Navarro et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

Julia Leitman et al.

NATURE COMMUNICATIONS (2013)

Article Pharmacology & Pharmacy

SKF83959 Is a Potent Allosteric Modulator of Sigma-1 Receptor

Lin Guo et al.

MOLECULAR PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na+ Channel with 4-Fold Symmetry

Dilshan Balasuriya et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Neurosciences

Association between a variant of the sigma-1 receptor gene and Alzheimer's disease

Agnes Feher et al.

NEUROSCIENCE LETTERS (2012)

Article Clinical Neurology

Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice

Renzo Mancuso et al.

NEUROTHERAPEUTICS (2012)

Article Multidisciplinary Sciences

Sigma-1 Receptor Agonists Directly Inhibit NaV1.2/1.4 Channels

Xiao-Fei Gao et al.

PLOS ONE (2012)

Review Neurosciences

The sigma-1 receptor: roles in neuronal plasticity and disease

Said Kourrich et al.

TRENDS IN NEUROSCIENCES (2012)

Article Pharmacology & Pharmacy

σ-1 Receptor at the Mitochondrial-Associated Endoplasmic Reticulum Membrane Is Responsible for Mitochondrial Metabolic Regulation

Karla-Sue C. Marriott et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Article Pathology

Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease-Like Pathology and Cognitive Decline

Rodrigo Medeiros et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Cell Biology

Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels

Molly Johannessen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Article Clinical Neurology

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

Amr Al-Saif et al.

ANNALS OF NEUROLOGY (2011)

Review Clinical Neurology

Regional Cerebral Glucose Metabolism After Pridopidine (ACR16) Treatment in Patients With Huntington Disease

Mouna Esmaeilzadeh et al.

CLINICAL NEUROPHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Sig1R Protein Regulates hERG Channel Expression through a Post-translational Mechanism in Leukemic Cells

David Crottes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Medicine, Research & Experimental

Energy deficit in Huntington disease: why it matters

Fanny Mochel et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Chemistry, Medicinal

Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor

Erik Laurini et al.

ACS MEDICINAL CHEMISTRY LETTERS (2011)

Article Ophthalmology

Late-Onset Inner Retinal Dysfunction in Mice Lacking Sigma Receptor 1 (σR1)

Yonju Ha et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Article Biophysics

Demonstration of a Direct Interaction between σ-1 Receptors and Acid-Sensing Ion Channels

Stewart M. Carnally et al.

BIOPHYSICAL JOURNAL (2010)

Article Pharmacology & Pharmacy

In vivo pharmacology of the dopaminergic stabilizer pridopidine

Henrik Ponten et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

Review Clinical Neurology

Cognition and depression: the effects of fluvoxamine, a sigma-1 receptor agonist, reconsidered

Ian Hindmarch et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2010)

Article Neurosciences

Role of Presenilins in Neuronal Calcium Homeostasis

Hua Zhang et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Pharmacology & Pharmacy

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor κB

Johann Meunier et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Article Multidisciplinary Sciences

Direct involvement of σ-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

Gemma Navarro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Cell Biology

Voltage-gated sodium channel modulation by σ-receptors in cardiac myocytes and heterologous systems

Molly Johannessen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)

Article Behavioral Sciences

Sigma-1 receptor knockout mice display a depressive-like phenotype

Valentina Sabino et al.

BEHAVIOURAL BRAIN RESEARCH (2009)

Review Biochemistry & Molecular Biology

Mitochondrial calcium and the permeability transition in cell death

John J. Lemasters et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2009)

Review Cardiac & Cardiovascular Systems

Mitochondrial calcium transport in the heart: Physiological and pathological roles

Elinor J. Griffiths

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

Review Biochemistry & Molecular Biology

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

John Hardy

JOURNAL OF NEUROCHEMISTRY (2009)

Article Multidisciplinary Sciences

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1.GTP pathway

Shang-Yi Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Secondary Structure of Huntingtin Amino-Terminal Region

Mee Whi Kim et al.

STRUCTURE (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

Low density of sigma1 receptors in early Alzheimer's disease

Masahiro Mishina et al.

ANNALS OF NUCLEAR MEDICINE (2008)

Review Biochemistry & Molecular Biology

Huntington's disease: from pathology and genetics to potential therapies

Sara Imarisio et al.

BIOCHEMICAL JOURNAL (2008)

Article Biochemistry & Molecular Biology

Juxtaposition of the steroid binding domain-like I and II regions constitutes a ligand binding site in the σ-1 receptor

Arindam Pal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Pharmacology & Pharmacy

σ-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

Yelenis Herrera et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Article Ophthalmology

Sigma-1 Receptor Regulation of Voltage-Gated Calcium Channels Involves a Direct Interaction

Kissaou T. Tchedre et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Article Ophthalmology

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine

Sylvia B. Smith et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Article Oncology

Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines

Christopher P. Palmer et al.

CANCER RESEARCH (2007)

Article Pharmacology & Pharmacy

Identification of regions of the σ-1 receptor ligand binding site using a novel photoprobe

Arindam Pal et al.

MOLECULAR PHARMACOLOGY (2007)

Review Neurosciences

Do thin spines learn to be mushroom spines that remember?

Jennifer Bourne et al.

CURRENT OPINION IN NEUROBIOLOGY (2007)

Article Medicine, Research & Experimental

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

Omar Nelson et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Characterization of the cocaine binding site on the sigma-1 receptor

Yuenmu Chen et al.

BIOCHEMISTRY (2007)

Article Geriatrics & Gerontology

Sigma receptor type 1 gene variation in a group of Polish patients with Alzheimer's disease and mild cognitive impairment

Aleksandra Maruszak et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2007)

Article Pharmacology & Pharmacy

Interaction with σ1 protein, but not N-methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil

T Maurice et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Review Neurosciences

Molecular mechanisms of dendritic spine morphogenesis

T Tada et al.

CURRENT OPINION IN NEUROBIOLOGY (2006)

Article Geriatrics & Gerontology

A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease

N Uchida et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2005)

Article Clinical Neurology

Function of sigma1 receptors in Parkinson's disease

M Mishina et al.

ACTA NEUROLOGICA SCANDINAVICA (2005)

Article Pharmacology & Pharmacy

A perspective on the new mechanism of antidepressants: Neuritogenesis through sigma-1 receptors

M Takebayashi et al.

PHARMACOPSYCHIATRY (2004)

Article Multidisciplinary Sciences

Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation

T Hayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Neurosciences

Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice

F Langa et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2003)

Article Multidisciplinary Sciences

Regulating ankyrin dynamics: Roles of sigma-1 receptors

T Hayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)