Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 44, Issue -, Pages 1377-1384Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20160107
Keywords
-
Categories
Funding
- University of Brighton Studentship [WC003-30]
- BBSRC [BB/I007989/1, BB/I021345/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I007989/1, BB/I021345/1] Funding Source: researchfish
Ask authors/readers for more resources
RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is known about their specific roles in the development of multicellular organisms or human disease. This review focusses on the roles of DIS3L2 and XRN1 in the pathogenesis of human disease, particularly in relation to phenotypes seen in model organisms. The known diseases associated with loss of activity of DIS3L2 and XRN1 are discussed, together with possible mechanisms and cellular pathways leading to these disease conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available