Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 44, Issue -, Pages 510-516Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20150274
Keywords
microtubules; mitochondria; mitochondrial Rho GTPases (Miro); mitosis
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Funding
- Swiss National Science Foundation [PP00P3_13365]
- European Research Commission [337906-OrgaNet]
- ETH Zurich [ETH 21 11-2]
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During mitosis, cells undergo massive deformation and reorganization, impacting on all cellular structures. Mitochondria, in particular, are highly dynamic organelles, which constantly undergo events of fission, fusion and cytoskeleton-based transport. This plasticity ensures the proper distribution of the metabolism, and the proper inheritance of functional organelles. During cell cycle, mitochondria undergo dramatic changes in distribution. In this review, we focus on the dynamic events that target mitochondria during mitosis. We describe how the cell-cycle-dependent microtubule-associated protein centromeric protein F (Cenp-F) is recruited to mitochondria by the mitochondrial Rho GTPase (Miro) to promote mitochondrial transport and re-distribution following cell division.
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