Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 44, Issue -, Pages 499-504Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20150272
Keywords
endoplasmic reticulum; MAMs; mitochondria; protein kinase RNA-like ER kinase (PERK); plasma membrane; store operated Ca2+ entry (SOCE)
Categories
Funding
- KU Leuven [GOA/11/2009]
- Belgian Science Policy Office [IAP7/32]
- FWO [G0584.12]
- IWT Vlaanderen [111118]
Ask authors/readers for more resources
The endoplasmic reticulum (ER) is the main hub of cellular Ca2+ signalling and protein synthesis and folding. The ER moreover is the central player in the formation of contact sites with other organelles and structures, including mitochondria, plasma membrane (PM) and endosomes. The most studied of these, the ER-mitochondria contact sites, are crucial regulators of cellular Ca2+ homoeostasis, metabolism and cell death signalling. Protein kinase RNA-like ER kinase (PERK), an ER stress kinase and crucial signalling protein in the unfolded protein response (UPR), was found to be able to orchestrate contact sites between the ER and mitochondria and to be indispensable for the pre-apoptotic trafficking of calreticulin (CRT) at the PM during immunogenic cell death (ICD). Furthermore, PERK has recently been linked with ER and PM contact sites through the mechanism of store-operated Ca2+ entry (SOCE). Here we discuss emerging findings disclosing novel roles of the ER stress sensor PERK in orchestrating inter-organellar communication in the context of ER stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available