Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 44, Issue -, Pages 652-658Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20150255
Keywords
cholestenoic acid; cholesterol; hydroxycholesterol; liver X receptor (LXR); RAR-related orphan receptor gamma t (ROR gamma); sterol regulatory-element binding protein (SREBP)
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Funding
- Biotechnology and Biological Sciences Research Council [BB/I001735/1, BB/L001942/1]
- European Regional Development Fund/Welsh Government
- BBSRC [BB/L001942/1, BB/I001735/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L001942/1, BB/I001735/1] Funding Source: researchfish
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In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the immune system, particularly with respect to bacterial and viral infection and to T(h)17-cell development, and the role of oxysterols in breast cancer. We also discuss the value of oxysterol analysis in the diagnosis of disease.
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