Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 44, Issue -, Pages 94-108Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20150180
Keywords
biomass; cellulase; lytic polysaccharide monooxygenase; polysaccharide utilization loci
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/I014802/1]
- European Research Agency - Industrial Biotechnology Initiative - national research councils: Biotechnology and Biological Sciences Research Council [BB/L000423]
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes for Health Research [MOP-137134, MOP-142472]
- Canadian Foundation for Innovation
- British Columbia Knowledge Development Fund
- Biotechnology and Biological Sciences Research Council [BB/I014802/1] Funding Source: researchfish
- BBSRC [BB/I014802/1] Funding Source: UKRI
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Complex carbohydrates are ubiquitous in all kingdoms of life. As major components of the plant cell wall they constitute both a rich renewable carbon source for biotechnological transformation into fuels, chemicals and materials, and also form an important energy source as part of a healthy human diet. In both contexts, there has been significant, sustained interest in understanding how microbes transform these substrates. Classical perspectives of microbial polysaccharide degradation are currently being augmented by recent advances in the discovery of lytic polysaccharide monooxygenases (LPMOs) and polysaccharide utilization loci (PULs). Fundamental discoveries in carbohydrate enzymology are both advancing biological understanding, as well as informing applications in industrial biomass conversion and modulation of the human gut microbiota to mediate health benefits.
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