4.6 Article

A Toolbox for Organelle Mechanobiology Research-Current Needs and Challenges

Journal

MICROMACHINES
Volume 10, Issue 8, Pages -

Publisher

MDPI
DOI: 10.3390/mi10080538

Keywords

mechanobiology; mitochondria; organelles; microparticles; microfluidics; BioOptics; live-cell imaging

Funding

  1. Global Research Laboratory through the National Research Foundation of Korea (NRF) [NRF 2015K1A1A2033054]
  2. Wellcome Trust [214291/Z/18/Z]
  3. Wellcome Trust [214291/Z/18/Z] Funding Source: Wellcome Trust
  4. National Research Foundation of Korea [2015K1A1A2033054] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Mechanobiology studies from the last decades have brought significant insights into many domains of biological research, from development to cellular signaling. However, mechano-regulation of subcellular components, especially membranous organelles, are only beginning to be unraveled. In this paper, we take mitochondrial mechanobiology as an example to discuss recent advances and current technical challenges in this field. In addition, we discuss the needs for future toolbox development for mechanobiological research of intracellular organelles.

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