Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 17, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-019-0524-9
Keywords
Nuclear medicine; Diagnostic and therapeutic radionuclides; Drug carrier systems; Monoclonal antibodies; Nanoparticles; Microspheres; Radiopharmaceuticals; Theranostics; Multimodal imaging
Funding
- Russian Science Foundation [19-75-10010, N 19-75-00039]
- Russian Science Foundation [19-75-10010, 19-75-00039] Funding Source: Russian Science Foundation
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Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed.
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