Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 8, Issue 11, Pages 1985-2001Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201900463
Keywords
2-alkynylnitriles; bifunctional compounds; multicomponent reactions; heterocycles; chemoselective reactions
Categories
Funding
- CSIR, New Delhi, India
- DST, New Delhi, India
- UGC, New Delhi
- IIT Ropar
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2-Alkynylnitriles are a distinguished class of molecules known to play a pivotal role in the construction of a plethora of carbo-/heterocyclic compounds of biological and pharmaceutical importance. These molecules have been exploited as hydrolytically stable irreversible labels for cysteine tagging. In addition, they also form an important homologous series of complex interstellar molecules identified by radioastronomy. Therefore, in this Minireview, we highlight the numerous transformations and diverse reactions carried out with these substrates. Different reactions including nucleophilic additions and various carbo-/heterocycles formation are the prime focal areas of this article. Mechanistic aspects for certain reactions have also been delineated.
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