Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 47, Issue 1, Pages 3793-3803Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2019.1669617
Keywords
Diabetes; inflammation; wound healing; exosomes; angiogenesis
Categories
Funding
- Scientific Research Project of Liaoning Provincial Department of Education [JYTQN201719]
- Natural Science Foundation of Liaoning Province [20180550649]
- Journal Prep Services
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Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds.
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