Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 7, Issue 19, Pages 16112-16120Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.9b02886
Keywords
S,N-Codoped carbon quantum dots; Lotus root; GSH; 6-Thioguanine; Cell imaging
Categories
Funding
- National Natural Science Foundation of China [21765004, 21365006]
- Guangxi Science Foundation of China [2014GXNSFDA118004, 1598025-4]
- Innovation Project of Guangxi Graduate Education [YCSZ2013039]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2017-A5]
Ask authors/readers for more resources
S,N-Codoped carbon quantum dots (SNCQDs) with a quantum yield (QY) of 23% have been synthesized using lotus root as a carbon source and glutathione (GSH) as a nitrogen and sulfur source. The obtained SNCQDs exhibited many excellent features such as a simple preparation process, high fluorescence QY, satisfactory photostability, superior water solubility, and biocompatibility. The SNCQDs combined with Cu2+ were used as a novel off-on nanoprobe for 6-thioguanine (TG). Initial fluorescence is significantly quenched in this sensing system via electron transfer from SNCQDs to Cu2+. Fluorescence is recovered after adding TG owing to Cu2+-TG complex formation between Cu2+ and TG. A novel off-on fluorescent nanoprobe was presented for highly sensitive determination of TG. Under optimal conditions, the nanoprobe exhibited a wide linearity range of 0.005-80 mu mol/L for TG and a detection limit of 1.6 nmol/L. The designed off-on nanoprobe was successfully utilized for detecting TG in plasma and urine of a leukemia patient and imaging of TG in living T24 cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available