Journal
PLOS BIOLOGY
Volume 17, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3000113
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Funding
- National Health and Medical Research Council [637367, 461208, 637394, 1044754, 1069284]
- Australian Research Council [DP1094854]
- National Institutes of Health [NS047101, 5R01HL124209]
- Australian Postgraduate Award
- Walter and Eliza Hall Institute Edith Moffatt Scholarship
- Monash University Bridging Postdoctoral Fellowship
- Massachusetts General Hospital BioMEMS Center (National Institutes of Health) [EB002503]
- Monash Graduate Scholarship
- Monash International Postgraduate Research Fellowship
- Monash Postgraduate Publication Award
- Dora Lush Scholarship (National Health and Medical Research Council)
- BCH IDDRC [1U54HD0902565]
- State Government of Victoria
- Australian Government
- National Health and Medical Research Council of Australia [1069284] Funding Source: NHMRC
- Australian Research Council [DP1094854] Funding Source: Australian Research Council
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The initial host response to fungal pathogen invasion is critical to infection establishment and outcome. However, the diversity of leukocyte-pathogen interactions is only recently being appreciated. We describe a new form of interleukocyte conidial exchange called shuttling. In Talaromyces marneffei and Aspergillus fumigatus zebrafish in vivo infections, live imaging demonstrated conidia initially phagocytosed by neutrophils were transferred to macrophages. Shuttling is unidirectional, not a chance event, and involves alterations of phagocyte mobility, intercellular tethering, and phagosome transfer. Shuttling kinetics were fungal-species-specific, implicating a fungal determinant. beta-glucan serves as a fungal-derived signal sufficient for shuttling. Murine phagocytes also shuttled in vitro. The impact of shuttling for microbiological outcomes of in vivo infections is difficult to specifically assess experimentally, but for these two pathogens, shuttling augments initial conidial redistribution away from fungicidal neutrophils into the favorable macrophage intracellular niche. Shuttling is a frequent host-pathogen interaction contributing to fungal infection establishment patterns.
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