Journal
MRS COMMUNICATIONS
Volume 9, Issue 3, Pages 1098-1104Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrc.2019.104
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Funding
- Hong Kong Research Grants Council General Research Funds [HKU717713E, 17201017]
- National Key R&D Program of China [2017YFA0701303]
- Fundamental Research Program of Shenzhen [JCYJ20170818161757684, JCYJ20170307164610282]
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The regeneration of human tissues with complex anatomy such as gastrointestinal (GI) tract remains greatly challenging since it requires appropriate cell microenvironments with well-defined structural and biochemical cues. In this investigation, bilayer scaffolds consisting of different polymer nanofibers with orthogonal fiber orientations were prepared, in which vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) were encapsulated separately. The bilayer scaffolds have similar architecture to the anatomy of the GI tract and can achieve dual releases of VEGF and PDGF in sequential and sustained manners, which hold promise as appropriate cell microenvironments for promoting the regeneration of the GI tract.
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