Journal
JOURNAL OF SAUDI CHEMICAL SOCIETY
Volume 24, Issue 1, Pages 98-104Publisher
ELSEVIER
DOI: 10.1016/j.jscs.2019.09.007
Keywords
SiO2 nanoparticles; Cycloaddition reaction; Phosphorylated nucleoside analogues; Tumor-targeting ligands; Colon cancer cells
Categories
Funding
- Russian Foundation for Basic Research (RFBR) [18-515-05007]
Ask authors/readers for more resources
A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2',3'-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity. (C) 2019 King Saud University. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available