Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 477, Issue 4, Pages 952-956Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2016.07.006
Keywords
Zebrafish; Regeneration; Wnt/beta-catenin signaling; Spinal cord injury
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Funding
- PHS NRSA from NIGMS [T32GM007270]
- National Institutes of Health (NIH) [GM081619, P01]
- Howard Hughes Medical Institute Exceptional Research Opportunities Program (EXROP) for KH
- Howard Hughes Medical Institute for CAR
- Howard Hughes Medical Institute for JDB
- Howard Hughes Medical Institute Exceptional Research Opportunities Program (EXROP) for TMTP
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Unlike mammals, zebrafish can regenerate their injured spinal cord and regain control of caudal tissues. It was recently shown that Wnt/beta-catenin signaling is necessary for spinal cord regeneration in the larval zebrafish. However, the molecular mechanisms of regeneration may or may not be conserved between larval and adult zebrafish. To test this, we assessed the role of Wnt/beta-catenin signaling after spinal cord injury in the adult zebrafish. We show that Wnt/beta-catenin signaling is increased after spinal cord injury in the adult zebrafish. Moreover, overexpression of Dkk1b inhibited Wnt/beta-catenin signaling in the regenerating spinal cord of adult zebrafish. Dkk1b overexpression also inhibited locomotor recovery, axon regeneration, and glial bridge formation in the injured spinal cord. Thus, our data illustrate a conserved role for Wnt/beta-catenin signaling in adult and larval zebrafish spinal cord regeneration. Published by Elsevier Inc.
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