Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 477, Issue 4, Pages 749-754Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2016.06.130
Keywords
miR-199b-5p; BMSCs; Osteogenesis; GSK-3 beta; beta-catenin
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Funding
- National Natural Science Foundation of China [81402224, 81501890]
- Science and Technology Bureau of Hunan Province [2012FJ6001]
- Science and Technology Office of Changsha City [K1203040-31]
- Health and Family Planning Commission of Hunan Province [B2014-12]
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miR-199b-5p is up-regulated significantly during the osteogenesis process in human bone marrow stromal cells (BMSCs). Inhibiting miR-199b-5p notably reduces while over-expressing miR-199b-5p promotes the BMSCs osteoblast differentiation, suggested by the alternations of osteogenic genes expression, ALP activity and the ARS-stained mineral nodules. miR-199b-5p exerts its role in BMSC osteogenesis most probably through the GSK-3 beta/beta-catenin signaling pathway. In conclusion, the present study revealed for the first time that miR-199b-5p plays a positive role in osteoblast differentiation. (C) 2016 The Authors. Published by Elsevier Inc.
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