Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 471, Issue 1, Pages 135-141Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2016.01.164
Keywords
Diabetic retinopathy; Microvascular dysfunction; Long noncoding RNA; PI3k/Akt signaling
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Funding
- Shanghai Science and technology commission guiding project [14411971000]
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Microvascular dysfunction is an important characteristic of diabetic retinopathy. Long non-coding RNAs (IncRNAs) play important roles in diverse biological processes. In this study, we investigated the role of IncRNA-MEG3 in diabetes-related microvascular dysfunction. We show that MEG3 expression level is significantly down-regulated in the retinas of STZ-induced diabetic mice, and endothelial cells upon high glucose and oxidative stress. MEG3 knockdown aggravates retinal vessel dysfunction in vivo, as shown by serious capillary degeneration, and increased microvascular leakage and inflammation. MEG3 knockdown also regulates retinal endothelial cell proliferation, migration, and tube formation in vitro. The role of MEG3 in endothelial cell function is mainly mediated by the activation of PI3k/Akt signaling. MEG3 up-regulation may serve as a therapeutic strategy for treating diabetes-related microvascular complications. (C) 2016 Elsevier Inc. All rights reserved.
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