Journal
CELL REPORTS
Volume 28, Issue 6, Pages 1499-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.07.007
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Funding
- NIH [P30 CA016042, 5P30 AI028697]
- James B. Pendleton Charitable Trust
- UCLA Minor in Biomedical Research
- Silva Endowment as part of the Undergraduate Research Scholars Program at UCLA
- Ruth L. Kirschstein National Research Service Award [GM007185]
- Eugene V. Cota-Robles Fellowship
- National Institute of General Medical Sciences of the NIH [R25GM055052]
- Saul Martinez Scholarship
- Spitzer Family Foundation Fund
- Gill Endowment
- American Cancer Society [RSG-17-068-01-TBG]
- Department of Defense [W81XWH-13-1-0470]
- Margaret E. Early Medical Research Trust
- STOP CANCER [P50CA092131/UCLA]
- UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Rose Hills Foundation Innovator Grant
- UCLA's Jonsson Comprehensive Cancer Center, Broad Stem Cell Research Center, Clinical and Translational Science Institute
- Institute of Urologic Oncology
- NIH/NIDDK [R01 DK115477]
- UCLA's Technology Center for Genomics and Bioinformatics, Translational Pathology Core Laboratories
- UCLA's Institute for Quantitative and Computational Biology
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Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an agerelated expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. The increase in luminal progenitor cells may contribute to greater risk for growth-related disease in the aging prostate. Importantly, we demonstrate expansion of human luminal progenitor cells in BPH. In summary, we define a Trop2(+) luminal progenitor subset and identify an age-related shift in the luminal compartment of the mouse and human prostate epithelium.
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