Journal
CELL REPORTS
Volume 28, Issue 12, Pages 3249-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.07.039
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Funding
- Wellcome Trust [WT109965MA, 104553/z/14/z, 211050/Z/18/z]
- National Health and Medical Research Council of Australia (NHMRC) [1113293, 1071916, 1016629, 606788, 1120467]
- ARC Future Fellowship
- ARC DECRA Fellowship
- NIHR
- Oxford Martin School
- National Health and Medical Research Council of Australia [1120467] Funding Source: NHMRC
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Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer(+) cells derived from either human blood or murine lungs, we define the basic transcriptome of an activated MAIT cell in both species and demonstrate how this profile changes during the resolution of infection and during reinfection. We observe strong similarities between MAIT cells in humans and mice. In both species, activation leads to strong expression of pro-inflammatory cytokines and chemokines as well as a strong tissue repair signature, recently described in murine commensal-specific H2-M3-restricted T cells. Transcriptomes of MAIT cells and H2-M3-specific CD8+ T cells displayed the most similarities to invariant natural killer T (iNKT) cells when activated, but to gamma delta T cells after the resolution of infection. These data define the requirements for and consequences of MAIT cell activation, revealing a tissue repair phenotype expressed upon MAIT cell activation in both species.
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