Journal
CELL REPORTS
Volume 28, Issue 7, Pages 1717-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.07.043
Keywords
-
Categories
Funding
- Medical Research Council (MRC) Confidence in Concept (CiC) award [CiC4/21]
- MRC Arthritis UK Centre for Musculoskeletal Ageing Research
- Wellcome Trust Senior Fellowship [104612/Z/14/Z]
- Marie Sklodowska-Curie grant [705869]
- Roy J. Carver Trust
- NIH [R01HL147545]
- MRC [MC_PC_15032] Funding Source: UKRI
- Marie Curie Actions (MSCA) [705869] Funding Source: Marie Curie Actions (MSCA)
Ask authors/readers for more resources
Nicotinamide adenine dinucleotide (NAD(+)) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction in rodents. We aimed to establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD(+) metabolome and if it can alter muscle mitochondrial bioenergetics. We supplemented 12 aged men with 1 g NR per day for 21 days in a placebo-controlled, randomized, double-blind, crossover trial. Targeted metabolomics showed that NR elevated the muscle NAD(+) metabolome, evident by increased nicotinic acid adenine dinucleotide and nicotinamide clearance products. Muscle RNA sequencing revealed NR-mediated downregulation of energy metabolism and mitochondria pathways, without altering mitochondrial bioenergetics. NR also depressed levels of circulating inflammatory cytokines. Our data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available