Journal
ADVANCED HEALTHCARE MATERIALS
Volume 8, Issue 19, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201900813
Keywords
bioelectronics; capillary fibers; cytokines; drug delivery; electrophoresis; inflammation; ion exchange membranes; iontronics; organic electronics
Funding
- Swedish Foundation for Strategic Research [RIT15-0119]
- Advanced Functional Materials SFO-Center at Linkoping University
- International Interdisciplinary Laboratory for Advanced Functional Materials, Linkopings Universitet
- Onnesjo Foundation
- Knut and Alice Wallenberg Foundation
- Swedish Foundation for Strategic Research (SSF) [RIT15-0119] Funding Source: Swedish Foundation for Strategic Research (SSF)
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An organic electronic ion pump (OEIP) delivers ions and drugs from a source, through a charge selective membrane, to a target upon an electric bias. Miniaturization of this technology is crucial and will provide several advantages, ranging from better spatiotemporal control of delivery to reduced invasiveness for implanted OEIPs. To miniaturize OEIPs, new configurations have been developed based on glass capillary fibers filled with an anion exchange membrane (AEM). Fiber capillary OEIPs can be easily implanted in proximity to targeted cells and tissues. Herein, the efficacy of such a fiber capillary OEIP for modulation of inflammation in human monocytes is demonstrated. The devices are located on inflammatory monocytes and local delivery of salicylic acid (SA) is initiated. Highly localized SA delivery results in a significant decrease in cytokine (tumor necrosis factor alpha and interleukin 6) levels after lipopolysaccharide stimulation. The findings-the first use of such capillary OEIPs in mammalian cells or systems-demonstrate the utility of the technology for optimizing transport and delivery of different therapeutic substances at low concentrations, with the benefit of local and controlled administration that limits the adverse effect of oral/systemic drug delivery.
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