Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 478, Issue 1, Pages 162-167Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2016.07.074
Keywords
Ergothioneine; Antioxidant; Ageing; Neurodegeneration; Risk factor
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Funding
- National Medical Research Council of Singapore [NMRC/1264/2010/082/12]
- National University of Singapore Virtual Institute [VG-8]
- Alice Lim Memorial Fund [ALMFA/2010]
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Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potential cytoprotective effects, we examined how ET levels change with age. We found that whole blood ET levels in elderly individuals decline significantly beyond 60 years of age. Additionally, a subset of these subjects with mild cognitive impairment had significantly lower plasma ET levels compared with age-matched subjects. This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases. (C) 2016 Elsevier Inc. All rights reserved.
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