4.2 Review

Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models

Journal

EPILEPSY CURRENTS
Volume 19, Issue 6, Pages 390-396

Publisher

SAGE PUBLICATIONS INC
DOI: 10.1177/1535759719874787

Keywords

SUDEP; death; breathing; cardiac; arousal; animal models

Funding

  1. NIH/NINDS [R01 NS095842]
  2. Beth L. Tross Epilepsy Professorship at the University of Iowa, Carver College of Medicine

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Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a great challenge to studies in patients. Recently, there has been an increase in animal studies to try to better understand the pathophysiology of SUDEP. In this current review, we focus on developments through seizure-induced death models and the preventative strategies they may reveal.

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