Journal
ONCOLOGY LETTERS
Volume 18, Issue 5, Pages 5119-5128Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2019.10850
Keywords
exosome complex genes; mantle cell lymphoma; RNA degradation; gene expression profile
Categories
Funding
- National Natural Science Foundation of China [81800195]
- Interdisciplinary Medicine Seed Fund of Peking University [BMU2018MB004]
- Beijing Natural Science Foundation [7132183, 7182178]
- China Health Promotion Foundation [CHPF-zlkysx-001]
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Exosome complex (EXOSC) genes, which encode a multi-protein intracellular complex, mediate the degradation of various types of RNA molecules. EXOSCs, also known as polymyositis/scleroderma complexes, exist in eukaryotic cells and archaea, and primarily mediate 3 ' to 5 ' mRNA degradation. However, how EXOSC genes are implicated in processes of B-cell immune-associated pathways and B-cell tumorigenesis remains unclear. The present bioinformatics study indicated that 6 of 10 EXOSC genes, particularly the EXO.index, were able to predict the survival of patients with mantle cell lymphoma (MCL), by analyzing gene expression profiles of 123 patients with MCL from the Gene Expression Omnibus database. The results suggested that EXOSC gene expression may be a molecular marker for MCL. Compared with the whole transcript profile, patients with MCL with a high EXO.index exhibited poorer survival and decreased RNA levels, which was also verified in a second dataset. The EXOSC genes may be associated with DNA repair and B-cell activation pathways, which may be the cause of poorer survival of patients with MCL.
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