Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 59, Issue -, Pages 362-370Publisher
ELSEVIER
DOI: 10.1016/j.jff.2019.05.053
Keywords
EGCG; beta-Lactoglobulin; Delivery; Metabolic syndrome; Obesity; Diabetes
Categories
Funding
- Israeli Dairy Board
- Ministry of Health [3-12024]
- Diamond Rose Fund
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Enriching widely-consumed foods and beverages with nutraceuticals is an important disease-prevention strategy. (-)-Epigallocatechin-3-gallate (EGCG), the green-tea polyphenol, is a potent antioxidant with numerous attributed health benefits. However, it is bitter, astringent, and susceptible to oxidation. Herein we studied our recently developed beta-lactoglobulin (beta-Lg)-based delivery system, assessing its efficacy in the prevention of metabolic syndrome effects in a high-fat-diet (HFD)-induced obesity mice model. Metabolic effects were evaluated in mice fed either HFD or normal diet (ND), which concomitantly consumed either milk (1% fat) fortified with EGCG-beta-Lg complexes, or free EGCG, or water with EGCG or water only, for 12 weeks. HFD mice receiving EGCG-beta-Lg complexes in milk, had significantly lower liver-triglycerides levels compared to control (HFD-water) group. Moreover, compared to free EGCG in milk, EGCG-beta-Lg complexes significantly improved glucose tolerance in both diets. Thus, beta-Lg delivery system may improve the efficacy of polyphenols like EGCG in preventing the metabolic syndrome.
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