Journal
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
Volume 2019, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2019/1265175
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [81773850]
- Program of International Science and Technology Cooperation of the Ministry of Science and Technology [2013DFG32060]
- Science and Technology Major Project of Hunan Province [2017SK1020]
Ask authors/readers for more resources
Diabetes is a metabolic disease, partly due to hypoinsulinism, which affects similar to 8% of the world's adult population. Glibenclamide is known to promote insulin secretion by targeting beta cells. Autophagy as a self-protective mechanism of cells has been widely studied and has particular physiological effects in different tissues or cells. However, the interaction between autophagy and glibenclamide is unclear. In this study, we investigated the role of autophagy in glibenclamide-induced insulin secretion in pancreatic beta cells. Herein, we showed that glibenclamide promoted insulin release and further activated autophagy through the adenosine 5'- monophosphate (AMP) activated protein kinase (AMPK) pathway in MIN-6 cells. Inhibition of autophagy with autophagy inhibitor 3-methyladenine (3-MA) potentiated the secretory function of glibenclamide further. These results suggest that glibenclamide-induced autophagy plays an inhibitory role in promoting insulin secretion by activating the AMPK pathway instead of altering the mammalian target of rapamycin (mTOR).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available