Journal
JACC-CARDIOVASCULAR IMAGING
Volume 12, Issue 11, Pages 2332-2344Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcmg.2019.06.031
Keywords
cardiac magnetic resonance; extracellular volume (ECV); native T1
Funding
- National Institutes of Health [R01 HL131919, T32 EB003841]
- Siemens Medical Solutions USA, Inc.
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Myocardial native T1 and extracellular volume fraction (ECV) mapping have emerged as cardiac magnetic resonance biomarkers providing unique insight into cardiac pathophysiology. Single breath-hold acquisition techniques, available on clinical scanners across multiple vendor platforms, have made clinical T1 and ECV mapping a reality. Although the relationship between changes in native T1 and alterations in cardiac microstructure is complex, an understanding of how edema, blood volume, myocyte and interstitial expansion, lipids, and paramagnetic substances affect T1 and ECV can provide insight into how and why these parameters change in various cardiac pathologies. The goals of this state-of-theart review will be to review factors influencing native T1 and ECV, to describe how native T1 and ECV are measured, to discuss potential challenges and pitfalls in clinical practice, and to describe new T1 mapping techniques on the horizon. (C) 2019 by the American College of Cardiology Foundation.
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