Journal
VIRUSES-BASEL
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/v11080741
Keywords
hypervirulent FAdV-4; hepatitis-hydropericardium syndrome; pathogenesis; viral protein; host factor
Categories
Funding
- National Natural Science Foundation of China [31772771]
- National Key R&D Program of China [2016YFD0501102]
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Since 2015, severe outbreaks of hepatitis-hydropericardium syndrome (HHS), caused by hypervirulent fowl adenovirus serotype 4 (FAdV-4), have emerged in several provinces in China, posing a great threat to poultry industry. So far, factors contributing to the pathogenesis of hypervirulent FAdV-4 have not been fully uncovered. Elucidation of the pathogenesis of FAdV-4 will facilitate the development of effective FAdV-4 vaccine candidates for the control of HHS and vaccine vector. The interaction between pathogen and host defense system determines the pathogenicity of the pathogen. Therefore, the present review highlights the knowledge of both viral and host factors contributing to the pathogenesis of hypervirulent FAdV-4 strains to facilitate the related further studies.
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