Journal
TRENDS IN NEUROSCIENCES
Volume 42, Issue 11, Pages 759-762Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2019.08.003
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Funding
- National Institute on Aging [AG054617, AG05142]
- JPB Foundation
- University of Kansas Alzheimer's Disease Center [AG035982, AG060733, AG061194, AZ170111]
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Multiple features distinguish the mitochondria of Alzheimer's disease (AD) patients from those of unaffected individuals. The causes and consequences of these differences are informed by the recent finding by Fleck et al. (J. Neurosci., 2019) that pentatricopeptide repeat-containing protein 1 (PTCD1) gene variants associate with AD. This suggests a proximal or initiating role for mitochondria in AD.
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