Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 9, Pages 809-824Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.07.003
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Funding
- National Institutes of Health (NIH)/National Cancer Institute (NCI) [RO1CA194923, RO1CA216421, RO1CA228135, PO1CA229086]
- NY State Department of Health (NYSTEM) [C32563GG, C32587GG]
- American Association for Cancer Research (AACR) Leukemia Incyte Fellowship
- American Cancer Society [RSG-15-189-01-RMC]
- Leukemia and Lymphoma Society
- St. Baldrick's Foundation
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Epigenetic dysregulation plays a profound role in the pathogenesis of hematological malignancies, which is often the result of somatic mutations of chromatin regulators. Previously, these mutations were largely considered to alter gene expression in two dimensions, by activating or repressing chromatin states; however, research in the last decade has highlighted the increasing impact of the 3D organization of the genome in gene regulation and disease pathogenesis. Here, we summarize the current principles of 3D chromatin organization, how the integrity of the 3D genome governs immune cell development and malignant transformation, as well as how underlying (epi-)genetic drivers of 3D chromatin alterations might act as potential novel therapeutic targets for hematological malignancies.
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