Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 8, Pages 735-747Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.06.002
Keywords
-
Categories
Funding
- Cancer Council Victoria Postdoctoral Fellowship
- Sylvia and Charles Viertel Charitable Foundation
Ask authors/readers for more resources
Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8(+) memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in protecting against viral and bacterial infections is well established. Recent evidence suggests that TRM cells also play a vital part in preventing the development and spread of solid tumors. Here, we discuss the emerging role of TRM cells in anticancer immunity. We highlight defining features of tumor-localizing TRM cells, examine the mechanisms through which they have recently been shown to suppress cancer growth, and explore their potential as future targets of cancer immunotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available