Journal
TRENDS IN COGNITIVE SCIENCES
Volume 23, Issue 8, Pages 655-+Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2019.05.009
Keywords
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Funding
- National Institute for Mental Health (NIMH) [ZIA MH00288712, F32 MH116592-01A1]
- Canadian Institutes of Health Research (CIHR) [FDN-143212, PJT 159554]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN 06-066, RGPIN-2019-05176]
- Canada First Research Excellence Fund (Healthy Brains for Healthy Lives)
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002887] Funding Source: NIH RePORTER
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Studies of humans with focal brain damage and non-human animals with experimentally induced brain lesions have provided pivotal insights into the neural basis of behavior. As the repertoire of neural manipulation and recording techniques expands, the utility of studying permanent brain lesions bears re-examination. Studies on the effects of permanent lesions provide vital data about brain function that are distinct from those of reversible manipulations. Focusing on work carried out in humans and nonhuman primates, we address the inferential strengths and limitations of lesion studies, recent methodological developments, the integration of this approach with other methods, and the clinical and ecological relevance of this research. We argue that lesion studies are essential to the rigorous assessment of neuroscience theories.
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