Journal
TRENDS IN CELL BIOLOGY
Volume 29, Issue 11, Pages 849-851Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.08.002
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Funding
- Azrieli Foundation
- Marguerite Stolz Research Fellowship Fund
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Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.
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