4.6 Editorial Material

The Nucleolus as a Proteostasis Regulator

Journal

TRENDS IN CELL BIOLOGY
Volume 29, Issue 11, Pages 849-851

Publisher

ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.08.002

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Funding

  1. Azrieli Foundation
  2. Marguerite Stolz Research Fellowship Fund

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Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.

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