Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 118, Issue -, Pages 722-730Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.06.028
Keywords
Paper spray ionization; PS-MS; Ambient ionization; Clinical; Forensic; Reaction Monitoring; Environmental; 'Omics; 3D printing
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Paper spray ionization has grown to become one of the most successful ambient ionization methods within the past decade. Requiring little to no sample preparation and being remarkably simple to construct, this technique has seen application in a wide number of fields. This review approaches the mechanism of how paper spray works, and seeks to better classify what it is and is not in a rapidly expanding field of ambient techniques. Additionally, many applications of the technique in clinical, forensic, environmental, and reaction monitoring regimes are explored. Finally, perspectives towards the future of how paper spray could be utilized will be expanded upon, including unexplored substrates and possibilities for the 'omics space. Published by Elsevier B.V.
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