Journal
THROMBOSIS RESEARCH
Volume 181, Issue -, Pages 77-83Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2019.07.013
Keywords
Hypoxia; Hypoxia-inducible factor; Thrombosis; Thrombus formation
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Funding
- Department of Science and Technology, Government of India
- American Heart Association
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Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis and in human populations, but current therapies for thrombosis do not directly target hypoxia-responsive signaling pathways. The vascular response to hypoxia is controlled primarily by the hypoxia-inducible transcription factors (HIFs), whose target genes include several factors that regulate thrombus formation. In this article, we review the HIF-dependent and HIF-independent signaling pathways that regulate thrombus formation under hypoxic conditions. A better understanding of hypoxia-induced thrombus formation could lead to the development of novel prophylactic therapies for thrombosis.
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