Journal
TETRAHEDRON LETTERS
Volume 60, Issue 38, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.151043
Keywords
Ionic Liquid; Multicomponent reaction; Pyrroles; Solventless
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- CNPq [431391/2016-5]
- UDESC
- FAPESC
- FINEP
- FITEJ
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A general method for the synthesis of 1,2,3,4-tetrasubstituted pyrroles by [NMPH]CH3SO3 is reported. A full factorial design was performed in order to obtain a more robust and statistically correct optimum condition. The products were obtained in moderate to excellent yields. The developed methodology is very simple, cost-effective, and applicable for tri- and tetra-component reactions. (C) 2019 Elsevier Ltd. All rights reserved.
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