Journal
TETRAHEDRON LETTERS
Volume 60, Issue 38, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.151047
Keywords
Amathia lamourouxi; Betaine molecules; Bryozoans; Marine natural products
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Funding
- Griffith University
- Australian Postgraduate Award (APA) by the Australian Commonwealth Government
- A.R.C. [LE140100119]
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A chemical investigation of the eastern Australian endemic bryozoan Amathia lamourouxi led to the isolation of two unique betaine molecules, lamouroic acid trifluoroacetate and lamourimidazolinium trifluoroacetate. The structures of these molecules were determined using (+)-HRESIMS, 2D NMR and ECD analyses. The new compounds were screened for antiplasmodial, cytotoxic and antibacterial activity but were inactive at 40 mu M. Lamouroic acid trifluoroacetate is structurally related to the ubiquitous marine compound homarine, that has previously been shown to possess feeding deterrent properties, and this suggests that the new compound may also have an ecological role in the bryozoan. (C) 2019 Elsevier Ltd. All rights reserved.
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